Self-employed individuals can deduct a broad range of ordinary and necessary business expenses on Schedule C. Common deductions include home office expenses (simplified or actual method), business mileage at $0.70/mile, 100% of health insurance premiums, retirement plan contributions (SEP-IRA up to $70,000, Solo 401k, SIMPLE IRA), 50% of business meals, CPA and legal fees, business software and subscriptions, the business-use portion of your phone and internet, job-related education and training, business insurance, advertising and marketing, office supplies, and any other expense directly related to running your business. Keep detailed records and receipts for all deductions.